Here’s an old one - the winning(ish?) entry from the 4th LD48. The theme was Infection, here interpreted by a cheeky wave of communism spreading through cute icon-based conversations! From the readme:
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This game is a little real time strategy game. A body has been attacked by viruses. It’s on you to fight back the intruder. Only armed with an antidote you have to revert ill cells and defeat attacking viruses. Simple graphic and funny sounds helped the game to get rank 24 out of 66.

As a kid sometimes while driving, I’d imagine that I could shoot lasers out of the left and right sides of the car. The goal was to hit only curbs and nothing else, by turning them on and off to avoid gaps and such.

Can a child-hood fantasy be turned into a passable play mechanic? You be the judge!

In this game you travel through the brain, stomach and anus of your loved one, who unfortunately has cancer cells spreading throughout her body. Your job is to ‘clean up’ the curb, er, cancer.

The fifteen levels are each randomly generated using different rules, in later levels, her coughing causes (sort of) neat graphical effects.

Download the game
Download the source

Infection Wars is a multiplayer game where you use an “infectatron” vehicle to bring a population of “protoplasmoid” objects over to your color. There is a (fairly dim) AI to play against, but it’s best if you’re playing splitscreen head-to-head with one or more humans. It supports up to 4 players (with multiple joysticks/gamepads, preferably, or keyboard, or mouse).

It was written using PyGame (no OpenGL), and was my first game development contest entry. For a while, I had been driving around with a license plate holder based on the game.

This came in 9th in both innovation and completeness. I’m still rather pleased at how this game turned out - it’s a pretty simple game with some easy-to-understand but unusual mechanics. A few more hours could be spent on the game to fix a few shortcomings, including the fact that sometimes the protoplasmoids get hung up on walls, and that the AI is regrettably (and nigh-unplayably) dim.

Conways game of live ‘verses’ mode

I think it got a bronze pelly for something.

Slightly updated version can be found here: http://ds.diaspora.googlepages.com/home

The Destruction of the Viruses was a fairly ambitious (but not very innovative) game written for the Infection theme. The player had to clean out the insides of a computer by killing all the viruses that resided there. The viruses could clone themselves, so it wasn’t always that easy.

It played like a top-down shooter, with FPS controls, and used OpenGL to draw a level that could be rotated around the player.

There were many good intentions, and much love for the number 5 (there being 5 levels, 5 enemy types, and 5 weapon types), yet the game failed badly. The biggest mistake was a bug which made some parts of the game framerate dependent, leaving it extremely hard if you had a low framerate (it played as intended at about 180 FPS). It’s hard to say how it would have fared without the bug, but as it were, it placed about 23th.

You can get the compo version, or its source, if you want to, but I really must urge you not to! Better to get the ‘made working dist’ released a few days after the deadline. Both of them are for Windows and OpenGL.

I have an even better version around somewhere, that I haven’t packaged and released yet. I’ll do that soon, and then I’ll include it here.

A infected game. It didn’t get done but there is some odd graphics and strange swedish doctor sounds. Play the “game” online.

The player, shoot with a digicam on timer, yes, that is a floorball club I’m holding in my hand.

Insanity was my entry to LD4. The topic was “infection”. My idea was somewhat far-fetched and only in the story - the home town of Ian the janitor is befallen by an infection of insanity - so he has to beat up all the scientists at his workplace to find the cause of the infection and a cure.

Since I messed up the base engine (tried to somehow stuff the 3D into 2D), I wasn’t able to finish. There’s just one level with place holder graphics, but the level can’t be won and so the story never reaches its conclusion.

Cuzco’s Goat Bloat Game was my first LD entry. I was pretty amazed that I was able to make a whole game in 48 hours. This game got me hooked on game compos for life My fiddling skills were pretty weak at the time, so I had to speed up the music in Audacity so it wouldn’t sound like a dirge. I had fun with the goat AI - it’s pretty realistic. (Goats don’t like water, they climb on rocks, and when you chase them they run everywhere!) Since it was my first compo entry, my “fun” rating was rather low - I didn’t take enough time to balance the levels. Also, the coloring of the goats makes them look like bees, oops!